Pseudocatalase cream was identified and created by Dr. Karin U Schallreuter in Germany. There are many success stories (published by Dr. Schallreuter) of individuals who have traveled to Greifswald Germany and have been treated by Dr. Schallreuter in her clinic.
Here in the USA, a team at Northwestern University (Chicago) reverse engineered drug created by Dr. Schallreuter and it is now available here in the USA from some compounding pharmacies. There is one on line at www.pseudocatalase.com and you may find others in your city or town.
Generally PC-KUS (PseudoCatalase ‘Karin U Schallteuter) is prescribed and applied to the skin and is immediately treated with UVB Narrowband UVB311) light. This cream is the only one that I am aware of that’s applied before UVB NB Treatment, See http://www.vithappens.com/index.php/2010/07/protopic-and-elidel-and-uvb-nb-for-vitiligo/ for a discussion about UVB NB and Elidel or Protopic.
Taken from www.HomePhotoTherapy.com
From:
Skin & Allergy News
Patented Cream Can Hold Vitiligo at Bay
Author: Mike Bykowski, Staff Writer
Skin & Allergy News 29(5):32, 1998. © 1998 International Medical News Group.
SHORT HILLS, N.J. — A new cream can clear almost all traces of vitiligo from the hands and faces of over half of the patients with the disorder, Dr. Karin U. Schallreuter said at a conference on cosmeceuticals sponsored by International Business Communications.
Dr. Schallreuter, professor of clinical and experimental dermatology at the University of Bradford in West Yorkshire, England, and her colleagues have developed a patented cream, pseudocatalase, which in combination with calcium has achieved very high success rates in treating vitiligo.
The pseudocatalase cream only works in about 60% of Vitiligo patients, but in these patients, a treatment regimen combining pseudocatalase and calcium is up to 95% effective in clearing affected hands and faces, Dr. Schallreuter said.
She has treated 220 patients with this regimen. Pseudocatalase is not yet available. (webmaster’s note: at this time, Pseudocatalase IS available in Europe and the United States, and more patients have been treated with it.)
It remains unclear which patients are candidates for pseudocatalase, Dr. Schallreuter added. Current vitiligo treatments, including psoralens plus ultraviolet A radiation and steroids, very infrequently reach a significant efficacy rate, she noted.
Previous studies have indicated high levels of oxidative stress and low levels of epidermal catalase in the skin of patients with vitiligo. Pseudocatalase prevents oxidative stress in vitiliginous skin, she explained.
Dr. Schallreuter and her colleagues obtained punch biopsies from the involved and uninvolved skin of 18 vitiligo patients who were randomly selected before treatment with pseudocatalase; biopsies also were taken 6 and 12 months after treatment.
Patients applied pseudocatalase cream twice daily and were exposed to the sun or to a narrow band of ultraviolet B radiation twice a week.
Pseudocatalase reduced epidermal hydrogen peroxide in vitiliginous skin within 2 minutes at a rate 15 times faster than natural catalase. It also prevented vacuolation in melanocytes and keratinocytes and increased the number of functioning melanocytes in the involved epidermis, she said.
Hailed by some as the cure for vitiligo, Dr. Schallreuter takes a more realistic view. “Pseudocatalase will be a substitutional therapy, not a cure.”
Pseudocatalase also may have applications in other skin disorders, she said. For example, in one patient with xeroderma pigmentosum, it significantly reduced de novo actinic keratoses, basal cell carcinomas, and squamous cell carcinomas when applied topically over the entire body over a period of a year.
The US copy of Pseudocatalase has not been studied (to my knowledge). It may be more or less the same as the drug created bt Dr. Schallreuter.
The reader should review Dr. Schallreuter’s comments at her website
See http://www.vitiligo.eu.com/copies.htm
She is quite adamant and writes “ Copies of pseudocatalase are advertised worldwide. One ineffective copy of pseudocatalase cream plus calcium (P-CAT) has been advertised by Northwestern University in Chicago, Illinois, USA. Much confusion has taken place since the same name has been used from the original publication by Schallreuter et al 1995. The publications from Schallreuter et al on the subject of pseudocatalase formed the basis to support the efficacy of this product. More recently, Community Drug, Pittsburgh, USA, and McDonald’s Pharmacy, Vancouver, BC, Canada, are offering the same formulation for sale via the internet. There are no published results in the peer-reviewed journals on P-CAT.
Both creams have been examined and analysed in our laboratory in vitro and in vivo on vitiligo skin. The data clearly shows that both copied pseudocatalase complexes are identical but have very little effect in the removal of H2O2
I leave it to the reader to do more research and discuss this with his or her dermatologist.
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